What is IGENOMIX Oncodona test?
It is the most advanced genetic test for early detection of predisposition to inherited cancer. Oncodona uses Next Generation Sequencing (NGS) to analyze genetic information present in a panel of 21 genes, including BRCA1 and BRCA2 genes, in order to locate harmful mutations. The presence of a change or mutation in one of these genes assumes that the female carrier has an increased risk of developing breast and ovarian tumours, or other related cancers.
What genes are included in the Oncodona Test?
In addition to the BRCA1 and BRCA2 genes, the Oncodona test analyzes 19 more genes associated with risk of breast and ovarian cancer, which makes it a complete test.
What are the BRCA1 and BRCA2 genes?
BRCA1 and BRCA2 genes are the two most important genes that produce tumour suppressor protiens, which helps to repair damaged DNA. When these genes are functioning normally, they help to keep the breast, ovarian and other cells from dividing too rapidly or in uncontrolled way. If one of the genes has a mutation or changes, the function of the protein will be less or absent, leading to accumulation of new genetic mutations or changes. This will further lead to development of breast or ovarian cancer. The risk for a woman_of getting breast or ovarian cancer, as well as other related cancers, increases significantly if she inherits a damaging mutation in the BRCA1 and BRCA2 gene. The presence of mutations in BRCA1 and BRCA2 genes are 20 fold higher in women with precocious breast cancer diagnosed before age 40. Mutations in BRCA1 and BRCA2 account for approximately 5-10% of all breast cancers and between 10-15% of ovarian cancers.
Breast cancer is the most common tumour in todays women. The risk of a women suffering breast or ovarian cancer increases considerably if she inherits a harmful mutation in the BRCA1 gene or in the BRCA2 gene.
Why take the IGENOMIX Oncodona test?
- In these cases, it is essential to perform intensive tests to locate the cancer in its early stage so that there will be
- higher probability of successful treatment.
- In the case of people with mutations, there are several preventive options to deal with the cancer risk.
- These measures include intensified screening for early diagnosis.
When a mutation is detected in a family member, there is an increased risk that the other members of the family will be carriers of the same mutation.
People who inherit harmful mutations have 50% risk of passing the same to their children If a person has inherited a harmful mutation, it means that each of their brothers or sisters also has 50% chance of inheritting that mutation.
Who should do the test?
Oncodona is a simple and complete test for all women who want to have the maximum information about their personal risk of developing cancer. The information provided by Oncodona allows you to customise the breast and ovarian cancer prevention programme.
50% chance of inheriting and transmitting the harmful mutation
